Recently I was at a SULSA conference, and at the end, an expert panel was set up on stage, and with the audience they debated the following question: “should we sequence everyone at birth?”
Of course, I didn’t attend this debate. Why? For one simple reason: I knew they’d come to the wrong conclusion; and they did – the conclusion they came to was “not yet”, the argument being that we’re not ready, that we need to sit and think about the consequences first. It was a predictably cautious answer.
The thing is – revolutionary thinkers, the people who change history – they’re not cautious people. They’re also not committees. Let me just state at this point that I have a tremendous amount of respect for the panel members, some of whom I know personally, and all of whom I know professionally; but answers from crowds and committees always err on the side of caution. I’m not really a cautious person myself – there are enough cautious people around me to keep me in check!
Below, I’ve rewritten history in a cautious style. Let’s see how you like it:
At his home in Canada, a close family friend of Alexander Graham Bell persuades him to discontinue his work on the telephone, because in the future, big faceless commercial companies will use it to try and extract money from people, and pay-as-you-go lawyers will target the weak. The telephone is never invented.
On December 17th 1903, Jack Smith rushes up to the Wright Brothers and tells them “Stop! We shouldn’t build machines that will fly! In the future people will crash and die; others will use them for war. So please, stop – don’t invent flying!”
In 1928, a unknown laboratory assistant takes that contaminated petri dish and destroys it forever. We don’t need penicillin, we don’t need antibiotics – in the future we’ll breed antibiotic resistance, so to be cautious, let’s not bother with antibiotics at all.
Back in the 1790s, during a drunken argument in the local public house, Edward Jenner is eventually persuaded that giving cowpox to people in an attempt to immunise them against smallpox is a very bad idea. You see, in the future, vaccines will be discredited by a former glamour model and a fame-hungry ex-doctor. Better not to have them at all, so we can prevent this ever happening.
“Psssst! Tim! Don’t invent the internet – honestly, mate, bad idea – in future, most people will use it for porn, and and bad people will use it to bully others. Let it lie mate, we don’t need it….” - A friend of Tim Berners-Lee
“Ah shucks, you’re right – the public human genome effort is absolutely fine, it’ll get finished when it gets finished. Best to be patient, I’ll leave them to it” – J. Craig Venter
Do you like my version of history? :-)
The truth is we need a good balance; we need the cautious crowd, we need the majority to say “Wait! We need to think about this!”. At the same time, the people who change history are the outliers, the radicals, the people who say “F*ck it, I’m doing it anyway!”. Of course, these are not always good people (I’m invoking Godwin’s Law now before someone mentions Hitler in the comments).
My opinion is that, In terms of individual-level sequencing, let’s just get on with it. We’ve spoken about it for years, and I’m bored of waiting – in my first job in 1997, we were talking about personal genomics, except in those days it was called pharmacogenomics.
Let’s just start now. Every baby that’s born from today, and from now on, let’s sequence them, and let’s record their entire health history in a structured way that allows computers to analyse the results. In no time at all, we’d have hugely valuable, clinically relevant and actionable database.
What are we waiting for?!